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Biological activity - Wikipedia

The original capsule formulation of itraconazole may lead to variability in absorption and the plasma concentration. For the treatment of superficial fungal infections, this is not problematical because itraconazole accumulates at the infection site, making consistently high plasma concentrations unnecessary -- a characteristic that has been exploited in the development of a pulse regimen.

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Because consistent plasma concentrations are critical for the more serious systemic fungal infections, variable absorption of itraconazole from the capsules limits their application. Moreover, underlying disease processes and medical interventions can reduce absorption from the capsules in some patients with systemic fungal infections.

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To widen the beneficial application of itraconazole to include such patients, an oral solution and an intravenous formulation were developed. These formulations combine lipophilic itraconazole with hydroxypropyl-beta-cyclodextrin, a ring of substituted glucose molecules, which improves the solubility of itraconazole.

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The enhanced absorption and bioavailability of itraconazole from these new formulations make them ideal for the treatment of systemic fungal infections in a wide range of patient populations. The additional flexibility offered by the different routes of administration also means that itraconazole can be used in patients at high risk, such as children or those requiring intensive care, for whom the capsule formulation may be impractical.

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Asian Journal of Pharmacology and Toxicology AJPT aims to publish high quality original research work and provides a platform for scientists and academicians all over the world to promote, share, and discuss various novel aspects and methods in all areas of Pharmacology, Toxicology. This journal serves the scientific community as a forum to discuss current developments in the area of Pharmacology, Toxicology by exploring new innovations and application of genetic principles in medicine and public policy to attain highest publishing quality standards.

Asian Journal of Pharmacology and Toxicology AJPT is an open access, peer-reviewed, multidisciplinary, scholarly publishing journal, who publishes the contributions in the form of research articles, scientific reviews, clinical trial evidences, short communications, case reports etc. We provide digital object identifier DOI , which is electronic identification code or tag for all manuscripts, and serves international readers by publishing the original manuscripts and other related research work submitted by worldwide authors.

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Asian Journal of Pharmacology and Toxicology AJPT - ISSN: is open access; quarterly, online journal publishing mainly original Research Articles, Review, Short communications, Perspectives Innovative teaching methods, innovative practice approach, novel models, debates, view points , Invited articles, Case reports, Letter to Editor that contributes significantly to further the scientific knowledge predominantly devoted to reporting original contributions from all areas of the Pharmacology, Toxicology.

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Division of Geriatrics, Department of general Medlcme lnstltute of medicine Institute of madical sciences,Banaras. Cytogenetic bio-monitoring study in diabetes patients b Buccal cytome assay in exfoliated buccal epithelial cells. Ethnopharmacological Importance of Centella asiatica with Special Reference to Neuroprotective activity. Dubeya, Aruna Agrawal,a.